纳米颗粒药物载体系统的配方和表征用于拉西迪平
Ashveta Anant Dessai1, Mrunali Navin Kantak1, Cleona Elizabeth Mary DCruz1
1Department of Pharmaceutics, Goa College of Pharmacy, Panaji, India.
Assay and drug development technologies
|October 13, 2023
概括
这项研究开发了含有lacidipine的立体体纳米微粒,使其成为快速溶解的口腔膜. 这种新的配方通过改善药物输送和克服传统治疗的局限性来增强抗高血压治疗.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 拉西迪平是高血压的通道抗剂,由于广泛的第一通代谢,其口服生物利用率很低 (10%).
- 生物制药分类系统II类药物,如拉基迪平,需要先进的配方策略来提高治疗疗效.
研究的目的:
- 为了配制含有lacidipine的立方体纳米微粒,使其成为快速溶解的口腔膜.
- 提高拉基迪平在高血压管理中的口服输送和治疗潜力.
主要方法:
- 用脂质和表面活性剂的上下技术准备载有乳二平的立方体纳米纤维.
- 使用Box-Behnken设计优化工艺变量,以实现所需的颗粒大小和捕获效率.
- 优化的立方体被制成快速溶解的口腔膜,经过全面的表征和稳定性测试.
主要成果:
- 经过优化后的立方体分散体呈现出纳米色粒子大小 (116.8-341 nm) 和高捕获效率 (88.15%-97.1%).
- 由此产生的口腔膜显示了理想的特性,包括快速分解 (37.67 ± 3.68秒) 和高体外药物释放率 (91.44% ± 1.65%在6分钟内).
- 短期稳定性研究表明,薄膜特性没有显著变化,证实了配方的稳定性.
结论:
- 含有拉西迪平的立方体快速溶解口腔膜代表了对高血压管理的有希望的替代配方.
- 这种方法有效地解决了与常规拉基迪平治疗相关的生物可用性挑战.
- 开发的纳米纤维膜可以改善药物输送和患者对抗高血压治疗的遵从性.
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