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(II) 光热疗法:光激活H2O增强免疫疗法的案例研究

Ruijing Zhang^1,2, Hongxue Xu^2,3, Yuhang Yao²

¹Spin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, P. R. China.

Journal of the American Chemical Society

|October 13, 2023

概括

一种新型的无氧光疗剂Ni-2有效抑制瘤生长并激活免疫反应. 与aPD-L1结合,它抑制了远部瘤的生长和转移,为光免疫疗法带来了希望.

科学领域:

生物医学工程
材料科学
癌症学

背景情况:

但在瘤微环境中面临挑战.
瘤限制包括缺氧,复发,转移和免疫抑制,阻碍目前的光疗效.

研究的目的:

为增强光免疫疗法开发一种双功能,无氧的光疗剂 (Ni-2).
研究Ni-2在抗癌反应中产生热和基效应的能力.

主要方法:

设计和合成了近红外 (NIR) 响应的光热剂Ni-2.
评估了Ni-2的光物理特性,包括光稳定性,光声学和光热效应.
在携带CT26瘤的小鼠模型中评估Ni-2的疗效,单独和与抗编程死亡配体1 (aPD-L1) 结合使用.

主要成果:

在NIR照射下,Ni-2显示出高光稳定性,优异的光声/光热效应 (58.0%的转化效率),并将H2O2转化为基.
通过光热和H2O2诱导的联合作用,Ni-2抑制了瘤生长并激活了免疫反应.
使用aPD- L1的联合治疗抑制了远部瘤的生长和转移.

结论:

在癌症治疗中,Ni-2 是一种有效的无氧光疗剂.
尼2对光免疫疗法具有显著的潜力,特别是在与免疫检查点抑制剂相结合时.
三维过渡金属复合体代表了开发多功能"全合一"光热器的有希望的平台.

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