来自墨西哥塔马乌利帕斯州的老年西班牙裔成年人的结核病呈现和结果
Belinda A Medrano1, Miryoung Lee1, Gretchen Gemeinhardt2
1Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Brownsville campus, Brownsville, TX, USA.
Medicine
|October 13, 2023
概括
老年人面临更高的结核病 (TB) 死亡风险,尽管感染不那么复杂. 诸如酒精使用和低BMI等因素会使结果恶化,而社会支持则有所帮助. 建议针对老年人进行潜在结核病的查.
科学领域:
- 老年学是指老年学的学科.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 老年人 (≥65岁) 受结核病 (TB) 的影响不成比例,但在研究中代表性不足,特别是西班牙裔人口.
- 现有的结核病研究缺乏对影响老年人疾病进展和治疗结果的宿主因素的关注.
研究的目的:
- 研究与结核病相关的宿主因素和老年西班牙裔成年人的不良治疗结果.
- 为了比较老年人 (OA) 和年轻人 (YA,18-39岁;40-64岁) 之间的结核病特征和结核病结果.
主要方法:
- 使用墨西哥塔马乌利帕斯 (Tamaulipas) 的结核病监测数据进行的横截面研究 (2006-2013; n = 8381).
- 进行了多变量逻辑回归分析,以确定与年轻年龄组相比,老年人的关联.
主要成果:
- 老年人表现出较少复杂的结核病 (例如,较低的肺外结核病,较少的治疗放弃,较低的耐药性).
- 然而,OA在结核病治疗期间死亡的可能性显著更高 (adj-OR 3.9).
- 过度饮酒和低BMI增加了OA的死亡风险;社会支持 (联系) 有保护作用. 糖尿病与不良结果无关.
结论:
- 高龄是结核病治疗期间死亡率的关键预测因素,需要集中干预.
- 目前世界卫生组织的指导方针并不优先考虑OA用于潜伏结核病感染查,尽管它们的高风险状态.
- 将OA纳入潜伏结核病管理指南至关重要,特别是随着更安全,短期治疗的可用性.
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