了解患有状细胞疾病的成年人对药物坚持的多层次障碍
Ivie C Egiebor1, Karl J McCleary1, Jim E Banta1
1Loma Linda University, School of Public Health, Loma Linda, CA.
Medicine
|October 13, 2023
概括
抑郁症和卫生系统经验等障碍阻碍了状细胞疾病 (SCD) 的成年人遵守药物治疗. 解决这些多层次的挑战是改善患者健康和坚持治疗的关键.
科学领域:
- 血液学 血液学 血液学
- 公共卫生 公共卫生
- 健康心理学 心理健康心理学
背景情况:
- 有限的研究存在于成年人状细胞疾病 (SCD) 药物坚持的多层次障碍.
- 了解这些障碍对于开发有效干预措施至关重要.
- 药物坚持对于管理SCD和预防并发症至关重要.
研究的目的:
- 确定SCD成年人药物坚持的多层次障碍.
- 检查这些障碍与药物坚持水平之间的关系.
主要方法:
- 一项涉及130名患有SCD的成年人 (≥18岁) 在10家加利福尼亚诊所进行的横截面研究.
- 使用了药物坚持报告量表,关于药物的信仰问卷和患者报告结果测量信息系统 (PROMIS).
- 评估社区,机构和个人层面的障碍.
主要成果:
- 抑郁症的严重程度和对SCD药物的担忧与坚持相反相关 (r=-0.302,P<.001;r=-0.341,P<.001).
- 关于药物必要性的信念与坚持没有显著的相关性 (r=0.065,P=.464).
- 粘附障碍较少的患者报告了更高的药物坚持 (中位数=22对20.50,P=0.085).
结论:
- 多层次的障碍,包括个人 (抑郁症,药物问题) 和机构因素,显著影响成年SCD的药物坚持.
- 识别和解决这些障碍可以为有针对性的公共卫生战略提供信息.
- 干预措施的目的应该是改善成年SCD患者的药物坚持和整体健康.
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