在卵巢癌患者的新辅助化疗期间实施常规静脉血栓栓塞预防
Hannah D McLaughlin1, Patricia Greco1, Alli M Straubhar1
1University of Michigan, 1500 E. Medical Dr, Ann Arbor, MI 48109, United States.
Gynecologic oncology
|October 13, 2023
概括
在接受新辅助化疗的卵巢癌患者中,实施例行血栓预防显著降低了静脉血栓栓塞 (VTE) 率. 这种预防措施没有增加重大出血事件,突出其安全性和有效性.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床药房 临床药房
背景情况:
- 接受新辅助化疗的卵巢癌患者面临静脉血栓栓塞 (VTE) 的高风险.
- 实施质量改善举措对于管理这种脆弱人群中的VTE风险至关重要.
研究的目的:
- 评估常规血栓预防对接受新辅助化疗的卵巢癌患者VTE病例的影响.
- 通过比较其实施前后的主要出血事件来评估血栓预防的安全性.
主要方法:
- 在一个单一的医疗保健系统中,采用了准实验性的前后研究设计.
- 在2017年1月引入常规血栓预防治疗之前 (n=136) 和之后 (n=154) 的患者收集了有关静脉瘤发病率和出血事件的数据.
- 进行了单变量和多变量分析,以确定与VTE相关的因素.
主要成果:
- 实施前组的VTE比率从21.3%下降到实施后组的8.4% (p < 0.01).
- 常规血栓预防与静脉动脉突发症风险降低显著相关 (aOR 0.19;95% CI 0.07-0.53).
- 在两组之间没有观察到主要出血事件的显著差异 (0%对0.68%,p = 0.63).
结论:
- 在新辅助化疗期间进行例行血栓预防,有效降低卵巢癌患者的静脉瘤风险.
- 实施血栓预防是一种安全的策略,因为它不会导致严重出血并发症的增加.
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