相关实验视频
Updated: Jul 13, 2025

08:26
Nucleofection and In Vivo Propagation of Chicken Eimeria Parasites
Published on: February 14, 2020
7.0K
跨代表观遗传和免疫力在,在马雷克的疾病耐药性不同的
Yanghua He1, Robert L Taylor2, Hao Bai3
1Department of Human Nutrition, Food and Animal Sciences, University of Hawaii at Manoa, Honolulu, HI, 96822 USA; Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742 USA.
Poultry science
|October 13, 2023
概括
基因甲基化模式在中是跨代遗传的,影响马雷克病 (MD) 耐药性和免疫反应. 这些表观遗传标记对于控制MD瘤发生和改善整体免疫力至关重要.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 马雷克病病毒 (MDV) 在中引起T细胞淋巴瘤,导致严重的经济损失.
- 遗传和环境因素影响了MD的结果,需要对宿主病毒相互作用进行研究以更好地控制.
- 了解的跨代表观遗传 (TEI) 是管理MD的关键.
研究的目的:
- 为了分析具有不同MD抗性的品种的全基因组DNA甲基化模式.
- 为了确定与MD发病率和遗传相关的差异甲基化区域 (DMR).
- 调查DNA甲基化在MD瘤发生和免疫反应中的作用.
主要方法:
- 进行了全基因组DNA甲基化分析,对两种高度近亲繁殖的母 (MD-耐药63,MD-敏感72) 和五种复合先天性菌株 (RCS) 进行了分析.
- 在父系和RCS.之间确定了差异甲基化区域 (DMR).
- 在不同品种中评估了瘤生长和抗体反应.
主要成果:
- DNA甲基化模式与MD发病率有很强的关联.
- 对MD耐药和MD敏感的DNA甲基化标记被确定为跨代遗传.
- 在品系中观察到v-src DNA瘤生长和抗体反应的差异.
结论:
- 在中,DNA甲基化模式是跨代表观遗传的.
- 基因甲基化在MD瘤发生和其他免疫反应中起着至关重要的作用.
- 特定的甲基化区域可能充当一般免疫力的重要调节剂.
相关概念视频
Genomic Imprinting and Inheritance
34.6K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.6K
Complementation Tests
4.9K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
4.9K
Inheritance of Chromatin Structures
6.3K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.3K
Background and Environment Affect Phenotype
6.6K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.6K
Position-effect Variegation
6.3K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.3K
Epistasis
46.9K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
46.9K

