环境颗粒物与按温度分层的早产之间的关联:基于人口的妊娠队列研究
Wiessam Abu Ahmad1, Ronit Nirel2, Rachel Golan3
1Hebrew University-Hadassah School of Public Health, Hebrew University of Jerusalem, Israel.
怀孕期间暴露于细颗粒物 (PM2.5) 与早产 (PTB) 有关,温度改变了这一风险. 较低和较高的PM2.5暴露表明PTB风险增加,特别是在分别更冷或更热的条件下.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 空气污染研究研究
背景情况:
- 越来越多的证据将产前暴露于细颗粒物 (PM2.5) 和粗颗粒物 (PM10-2.5) 与早产 (PTB) 联系在一起.
- 环境温度对PM暴露和PTB之间的关联的影响仍未得到充分研究.
研究的目的:
- 调查以色列产前暴露于PM2.5和PM10-2.5与PTB之间的关联.
- 检查环境温度对PM-PTB关系的潜在影响变化的可能性.
主要方法:
- 在以色列 (2004-2015) 建立了一个基于人口的381,265个单独生育的队列,使用医疗保健数据.
- 每天的颗粒物和温度数据是从基于卫星的时空模型 (1x1公里分辨率) 中获得的.
- 混合效应的考克斯回归模型被用来评估平均怀孕暴露和PTB之间的关联,调整为共变量.
主要成果:
- 与中等水平相比,在低 (第一五位数) 和高 (第五五位数) 暴露水平上,PM2.5暴露与PTB风险增加有关 (HRs:1.18和1.07).
- 温度改变了PM2.5-PTB相关性:低温放大了高PM2.5暴露的风险 (HR: 1.21),而高温放大了低PM2.5暴露的风险 (HR: 1.48).
- 在高温下第五个PM2.5五分位数 (HR:0.92) 和在低温下第一个五分位数 (HR:0.93) 中观察到相反的趋势.
结论:
- 产前的PM2.5暴露与早产有关,具有U形的暴露-反应曲线.
- 环境温度显著改变了PM2.5暴露与早产风险之间的关联.
- 纳入气候因素对于全面了解PM相关的PTB风险至关重要.
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