在中老年和老年中国受试者中,血高级糖化终端产品水平和认知功能之间的关系
Xiaohui Zhang1, Qiuping Zhang2, Ziyan Ren1
1Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren'ai Road, Suzhou, 215123, China.
International journal of hygiene and environmental health
|October 13, 2023
概括
高水平的先进糖化终产物 (AGEs),特别是S-甲基-L-氨酸 (CMC) 和Nδ-(5--5-甲基-4-imidazolon-2-yl) -ornithine (MG-H1),与较差的认知表现和中国成年人认知障碍的风险增加有关.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 生物化学 生化学
背景情况:
- 认知能力下降是老年人群日益关注的一个问题.
- 先进的糖化终产品 (AGEs) 与与年龄相关的疾病有关.
- 了解AGE与认知之间的联系对于开发干预措施至关重要.
研究的目的:
- 调查循环高级糖化终产物 (AGEs) 与中年和老年中国成年人的认知功能之间的关联.
- 确定导致认知障碍的特定AGE.
主要方法:
- 一项涉及1834名参与者的横截面研究.
- 使用迷你精神状态检查 (MMSE) 评估认知表现.
- 使用UPLC-MS/MS测量的自由AGE (CML,CEL,CMC,MG-H1) 的血水平.
- 用于确定关联的多变量回归分析.
主要成果:
- 在血CMC和MG-H1水平和MMSE得分之间发现了显著的负相关性.
- 高CMC和MG-H1三位数与轻度认知障碍 (MCI) 的风险增加有关.
- 综合AGE指数 (WQS) 也显示了与MMSE的负相关性,并增加了MCI风险.
结论:
- 循环AGE,特别是CMC和MG-H1,与中国成年人的认知障碍有关.
- 这些AGE可能是认知衰退的关键因素.
- 需要进一步的纵向研究来证实这些发现.
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