葡萄种子提取物与deferasirox结合,可以缓解铁过载,氧化应激,炎症和肝脏功能障碍在贝塔沙勒西米亚儿童中
Sayeh Mottaghi1, Hassan Abbaszadeh2
1Department of Pediatrics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Complementary therapies in clinical practice
|October 13, 2023
概括
在患有β-thalassemia major (β-TM) 的儿童中补充葡萄种子提取物 (GSE) 有助于减少铁过载,炎症和肝损伤. GSE还改善了抗氧化剂标记,显示出与标准铁化一起作为补充疗法的潜力.
科学领域:
- 生物化学 生物化学
- 儿科血液学 儿科血液学
- 营养科学 营养科学
背景情况:
- 铁过载是β-thalassemia major (β-TM) 的严重并发症,导致不可逆转的组织损伤.
- 标准的铁化疗法可能有局限性,需要探索补充治疗方法.
研究的目的:
- 评估葡萄种子提取物 (GSE) 作为 β-TM 的儿科患者的辅助治疗的疗效和安全性.
- 为了研究GSE的铁化,抗氧化,抗炎和肝保护作用.
主要方法:
- 一项为期4周的随机对照试验,涉及60名患有β-TM的儿科患者.
- 参与者除了标准的deferasirox治疗外,每天接受100mg的GSE或安慰剂.
- 关键生物标志物包括铁指数,肝酶,炎症标志物和氧化应激标志物在干预前和后被测量.
主要成果:
- GSE补充剂显著降低了血清铁,费里丁,ALT,AST,TNF-α和hs-CRP的水平.
- GSE显著增加了总结铁能力 (TIBC) 和改善了氧化应激标志物 (MDA,GSH).
- 两组之间没有观察到SOD活性或血红蛋白度的显著差异.
结论:
- 葡萄种子提取物 (GSE) 对患有β-TM的儿童有显著的健康益处.
- GSE有效地减轻铁负担,氧化应激,炎症和肝脏功能障碍.
- 作为一种安全和有益的补充疗法,GSE在管理β-TM并发症方面表现有前途.
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