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Updated: Jul 13, 2025
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A 3D Organotypic Melanoma Spheroid Skin Model
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没有避免的黑色素瘤的预后
Martin G Cook1, Megan Grant2, Yvonne Sylvestre3
1Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Macclesfield SK10 4TG, UK; Royal Surrey NHS Foundation Trust, Guildford, UK; Division of Clinical Medicine, University of Surrey, Guildford, Surrey, UK; Members of EORTC Melanoma Pathology Working Group, Belgium.
Pathology, research and practice
|October 13, 2023
概括
避免黑色素瘤变体,包括成熟和结节/乳头瘤类型,表现出与表面传播黑色素瘤相似的生存结果. 由于病例数有限,需要对乳头瘤变异进行进一步的研究.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 性黑色素瘤有不同的预后可疑变体,但有限的后续研究存在.
- 评估未经避免的黑色素瘤亚型的预后对于患者管理至关重要.
研究的目的:
- 与表面扩散黑色素瘤 (SSM) 相比,评估不同未经避免的黑色素瘤变体的预后.
- 进行一项多中心研究,评估各种亚型的黑色素瘤存活率.
主要方法:
- 一项多中心的研究包括来自英国,澳大利亚和意大利的被诊断患有成熟性NAEVOID黑色素瘤,结节性/乳头瘤性NAEVOID黑色素瘤和SSM的患者.
- 使用Cox比例危险回归和细灰回归模型分析了生存数据,并根据临床因素和竞争风险进行了调整.
主要成果:
- 在英国患者中,成熟的未经避免的黑色素瘤与SSM相比,黑色素瘤死亡风险不显著降低 (SHR 0.40,95% CI 0.12-1.31).
- 在随访期间,在英国,澳大利亚或意大利的结节性/乳头性无性黑色素瘤患者中没有观察到黑色素瘤死亡.
- 澳大利亚和意大利的队列也显示,在最小的随访期后,在未经避免的黑色素瘤患者中没有黑色素瘤死亡.
结论:
- 在内性黑色素瘤和表面传播黑色素瘤之间,死亡风险没有显著差异.
- 结节性/乳头性无菌性黑色素瘤患者的死亡风险似乎不高于SSM患者.
- 鉴于病例数不多,对 papilomatous naevoid 变种预后的评估受到限制.
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