推进剂量与连续输注上腺素和上腺素的制备/施用:一个模拟
Hannah Morley1, Robert Seabury2, Katie Parsels1
1SUNY Upstate University Hospital, 750 E Adams St, Syracuse, NY 13210, United States of America.
The American journal of emergency medicine
|October 13, 2023
概括
上腺素和上腺素的推进剂量 (PD) 管理比连续输注 (CI) 更快,但具有更高的药物错误风险. 药剂师在PD中出现了更多的错误,主要是由于稀释问题,突出了关键的安全问题.
科学领域:
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
- 患者安全 患者安全
背景情况:
- 低血压是急诊室 (ED) 和重症监护室 (ICU) 的常见和严重并发症.
- 上腺素和上腺素通常用于管理低血压,通常是通过连续输液 (CI).
- 推量 (PD) 给药提供了另一种选择,但缺乏关于制备/给药效率和错误率的比较数据.
研究的目的:
- 为了比较推量剂 (PD) 与连续输注 (CI) 上腺素和上腺素的制备和施用时间.
- 评估与PD和CI方法相关的制备和施用错误的发生率.
- 在ED/ICU药剂师准备药物时评估这些参数.
主要方法:
- 一项交叉模拟研究,涉及16名ED/ICU药剂师.
- 使用多静脉静脉注射训练手臂套件进行现实的模拟.
- 测量的主要结果:总制备和施用时间 (秒).
- 测量的次要结果:主要的制备和施用错误 (≥5倍的过量).
主要成果:
- PD 显示总制备和施用时间显著加快 (大约2小时). 70年代减少与CI).
- PD导致更高的主要制备和施用错误率 (18.8%的PD制备),稀释错误是主要原因.
- 连续输注 (CI) 没有重大准备和注射错误.
结论:
- 虽然PD上腺素和上腺素为药剂师提供更快的施用时间,但它们与重大准备错误的风险增加有关.
- 稀释错误是导致PD药物制备中过量服用的关键因素.
- 需要进一步的策略来减轻与重症监护机构的PD药物管理相关的错误风险.
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