通过释放氧化的安西林聚合物基质,增强对抗生素耐药细菌的抗菌功效
Yi Wu1, Mark R Garren1, Lori M Estes Bright1
1School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, United States.
Journal of colloid and interface science
|October 13, 2023
概括
新的聚合物材料释放氧化和安培来对抗抗生素耐药细菌. 这种双重作用的方法增强了医疗器械的抗菌表面,减少了细菌的生存能力,并显示了生物相容性.
科学领域:
- 生物材料科学 生物材料科学
- 传染病研究 传染病研究
- 聚合物化学 聚合物化学
背景情况:
- 抗生素耐药细菌是一个重大的全球健康挑战,在医疗机构增加了病率和死亡率.
- 开发新的抗菌表面对于预防和治疗与医疗器械相关的感染至关重要.
研究的目的:
- 制造和表征具有双作用分子 (SNAPicillin) 的医疗级聚合物,以增强抗菌性能.
- 评估从这些聚合物表面释放的氧化和安培的目标释放量.
- 评估开发材料的体外抗菌疗效和生物相容性.
主要方法:
- 用于将SNAP西林纳入医疗级聚合物中的溶剂蒸发过程.
- 通过扫描电子显微镜和静态接触角测量进行表面表征.
- 使用基于化学发光的分析仪量化释放的氧化和通过UV视光谱学SNAPicillin扩散的量化.
- 在实验室中对抗黄金葡萄球菌的抗菌活性和对3T3小鼠纤维细胞的细胞毒性进行了评估.
主要成果:
- 含有SNAPicillin的聚合物薄膜显示氧化的持续释放 (在24小时内释放高达2.96 × 10−7mol cm−2).
- 超过79%的SNAP西林储备在24小时化后仍然存在聚合物中,这表明长期治疗潜力.
- 经过修改的表面实现了>95%的可活性金黄色葡萄球菌的减少.
- 经过SNAPicillin修饰的表面对3T3小鼠纤维细胞没有细胞毒性作用,证实了体外生物相容性.
结论:
- 素排泄聚合物通过氧化物和安培的联合释放提供双重作用的抗菌机制.
- 这些材料有望增强医疗器械表面的抗菌特性,打击耐药细菌菌株.
- 证明的生物相容性支持这些新型抗菌聚合物材料的潜在临床应用.
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