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在2型糖尿病中每周使用一次icodec胰岛素的最佳使用:对2期和3期随机对照试验的更新元分析
Deep Dutta1, Lakshmi Nagendra2, Sowrabha Bhat3
1Department of Endocrinology, Center for Endocrinology Diabetes Arthritis & Rheumatism (CEDAR) Superspeciality Healthcare, Dwarka, New Delhi, India.
Diabetes & metabolic syndrome
|October 13, 2023
概括
在52周的时间里,Icodec胰岛素在2型糖尿病 (T2D) 患者中显示出与其他基底胰岛素相比的HbA1c降低. 虽然一般耐受性很好,但icodec.的注射部位反应和体重增加率更高.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 之前对2型糖尿病 (T2D) 治疗方法的元分析包括有限的2期试验.
- 五个大型的第三阶段随机对照试验 (RCT) 已经发表在T2D中的icodec使用.
- 这一系统性审查和元分析提供了对icodec的有效性和安全性的最新评估.
研究的目的:
- 评估iCodec与其他基底胰岛素在T2D管理中的有效性.
- 评估icodec的安全性,包括不良事件和血糖控制.
- 建立在T2D中使用icodec的最佳实践.
主要方法:
- 对已发表的涉及T2D患者的RCT进行系统审查和元分析,这些RCT涉及T2D患者接受了icodec.
- 主要结局:HbA1c与基线的变化.
- 二次结果:血糖指标的变化和不良事件,包括低血糖和注射部位反应.
主要成果:
- 与其他基底胰岛素相比,Icodec在16周显示出可比的HbA1c降低,但在26周和52周显著更好的降低.
- 在16周和52周使用icodec,患者的HbA1c<7%的比例更高.
- 增加了1级和2级低血糖的比率被发现与50%的icodec加载剂量.
- 在26周使用icodec时,注射部位反应和体重增加的发生率较高.
结论:
- 伊科德克胰岛素耐受性良好,并提供与T2D中的其他基底胰岛素相比的血糖有效性.
- 由于降血糖的风险增加,需要仔细考虑剂量策略,例如加重剂量.
- 在iCodec治疗期间,建议对注射部位反应和体重增加进行监测.
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