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Updated: Jul 13, 2025

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
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PTBP2衰减通过促进神经元基因的替代拼接来促进纤维细胞转化为神经元的转化

Binglin Zhu1, Emily Fisher2, Li Li2

  • 1Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA; Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.

Stem cell reports
|October 13, 2023
PubMed
概括

直接将皮肤细胞转化为神经元是低效的. 这项研究表明,减少PTBP2蛋白通过促进神经元特异性基因拼接,与RBFOX3 (NeuN) 合作,增强了这一过程.

关键词:
有GABA活性的神经元在 PTBP2 中.在RBFOX3中使用RBFOX3.通过RNA拼接进行RNA拼接.替代性拼接是一种替代性的拼接.直接转换的直接转换诱导的神经元诱导的神经元nPTBTB 的时间重编程是重新编程.通过转差异化转化.

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