调解分析量化了可归因于妊娠年龄较小的婴儿死产风险的大小
Kylie Crawford1, Jesrine Hong2, Sailesh Kumar3
1Mater Research Institute, University of Queensland, Brisbane, Australia (Drs Crawford, Hong, and Kumar); University of Queensland Mayne Medical School, University of Queensland, Brisbane, Australia (Drs Crawford, Hong, and Kumar); School of Public Health, University of Queensland, Brisbane, Australia (Dr Crawford).
American journal of obstetrics & gynecology MFM
|October 13, 2023
概括
对于妊娠年龄来说小 (SGA) 对许多因素的死产风险进行调解. 针对SGA的干预措施是最有效的,当SGA是胎儿死亡的主要贡献者时,就像在孕前症中看到的那样.
科学领域:
- 围产期流行病学 围产期流行病学
- 孕产妇和胎儿的医学
- 公共卫生 公共卫生
背景情况:
- 死产的风险通常与胎盘功能障碍有关,导致子宫内生长率低于最佳,并且对于妊娠年龄 (SGA) 婴儿来说很小.
- SGA婴儿面临着死产的高风险,强调了解这种关系的重要性.
研究的目的:
- 调查已知的死产风险因素的影响.
- 为了确定与死产相关联的风险因素,通过SGA出生显著调解.
主要方法:
- 澳大利亚昆士兰州 (2000-2018) 出生的回顾性队列研究.
- 多变量物流回归和反事实调解分析,通过SGA评估风险因素的间接影响.
- 在SGA和适合怀孕年龄的婴儿之间对死产风险的比较.
主要成果:
- 分析了超过925,000个出生,其中9.9%被归类为SGA.
- 许多风险因素,包括母亲的年龄,社会经济地位,种族,吸烟,无产妇,多胎妊娠,辅助受孕,妊娠前和病,通过SGA显著调解.
- 孕前炎症 (66.7%),无产儿 (61.6%) 和吸烟 (29.4%) 是SGA介导的死产风险的最高比例.
结论:
- 对于妊娠年龄来说小是一个重要的调解者,将各种妊娠风险因素与死产联系起来.
- 旨在通过减轻SGA减轻死产风险的干预措施在SGA是导致胎儿死亡的主要途径时具有最大影响.
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