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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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无形固体分散物的聚合物诱导化学降解是由药物-聚合物相互作用驱动的,用于物理稳定

Taro Kojima1, Junpei Takeda1, Yang Song2

  • 1Analytical Development, Pharmaceutical Sciences, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

International journal of pharmaceutics
|October 13, 2023
PubMed
概括

在无形固体分散 (ASD) 中的分子间相互作用可以增强物理稳定性,但可能会降低化学稳定性. 活性药物成分 (API) 和基甲基纤维素酸 (HPMCAS) 之间的特定相互作用与这两种结果有关.

关键词:
无形固体的分散性固体.化学稳定性 化学稳定性药物聚合物兼容性 药物聚合物兼容性分子间相互作用 分子间相互作用分子间重新排列的分子间安排.喷雾干燥 喷雾干燥固态NMR是一种固态NMR.

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