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针对SARS-CoV-2的逆转基因系统:开发和应用

Hou-Li Cai1, Yao-Wei Huang2

  • 1Department of Veterinary Medicine, Zhejiang University, Hangzhou, 310058, China.

Virologica Sinica
|October 13, 2023
PubMed
概括

反向遗传系统可以对SARS-CoV-2基因组进行操纵,从而创建修改后的病毒和复制品. 这些工具对于研究病毒,开发抗病毒药物和制造疫苗至关重要.

关键词:
传染性克隆的病毒.活体减弱疫苗可以使用.复制品 复制品 复制品反向遗传学系统的反向遗传学系统这就是SARS-CoV-2病毒.

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Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...