在社会隔离期间,突触平衡中断和人类皮质中关联性长期潜能部分封闭在社交隔离期间
Peng Zhang1, Juan Yan2, Jiao Wei3
1School of Psychology, Beijing Key Laboratory of Learning and Cognition, Capital Normal University, Beijing 100048, China.
Journal of affective disorders
|October 13, 2023
概括
社会隔离会损害人脑中的突触平衡和关联性可塑性. 这种干扰会影响神经网络,导致声明性记忆性能降低.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 人体生理学 人体生理学
背景情况:
- 社会隔离,在军事环境中普遍存在,并由COVID-19大流行扩大,影响到一般人口.
- 突触稳态和关联性可塑性是神经网络功能和适应性行为的基础.
研究的目的:
- 研究社会隔离对人体突触强度和长期强化 (LTP) 类可塑性的影响.
- 确定这些变化的电生理和行为标记.
主要方法:
- 使用脑电图 (EEG) 来分析theta活动.
- 采用跨磁刺激 (TMS) 来测量运动唤起的潜力 (MEP).
- 应用配对关联刺激 (PAS) 来评估类似LTP的可塑性和行为表现的单词对任务.
主要成果:
- 社会隔离扰乱了突触平衡,由改变的EEG θ活动和TMS引起的MEP证明.
- 配对的关联刺激显示了类似LTP的可塑性部分封闭.
- 在声明性记忆任务中的行为表现下降.
结论:
- 社会隔离会对人脑皮层的突触恒常性和关联性LTP类可塑性产生负面影响.
- 这些神经干扰与声明性记忆功能减弱相关.
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