无脊椎动物中的FicD基因:转子体,病原体和集成病毒的故事
Umberto Rosani1, Sofia De Felice1, Riccardo Frizzo1
1Department of Biology, University of Padova, 35121 Padova, Italy.
Gene
|October 13, 2023
概括
横向基因转移 (HGT) 解释了共享的基因家族. 含有FIC域的酶 (FicDs) 广泛存在,有证据表明HGT和重复有助于它们转移到病毒中.
科学领域:
- 基因组学就是基因组学.
- 分子生物学分子生物学
- 进化生物学 进化生物学
背景情况:
- 横向基因转移 (HGT) 是跨多种物种基因分布的一个重要机制.
- 含有FIC域的酶 (FicDs) 催化AMPylation,这是一个关键的翻译后修改.
- 不同生命形式中FicDs的流行和进化动态仍然不完全理解.
研究的目的:
- 调查FicD基因在各种种群中的分布和进化史.
- 为了确定涉及FicDs的HGT和基因重复的实例.
- 探索FicDs在病毒病原发生中的潜在作用.
主要方法:
- 对FicD基因序列的遗传学分析.
- 进行比较基因组学,以识别FicD的正义词和对义词.
- 基因家族和病毒基因组的生物信息分析.
主要成果:
- 在原始体和微生物真核生物中发现了保存的FicD正体,扩大了它们已知的分布.
- 在几个无脊椎动物群体中观察到FicDs的基因重复,包括虫,寄生虫和双虫.
- 在几种与无脊椎动物相关的dsDNA病毒中发现了FicD基因,与宿主FicD有遗传联系,表明HGT和重复事件.
结论:
- FicD基因的进化历史比以前认可的更广泛,涉及HGT和重复.
- 这些机制可能有助于病毒从细菌和真核宿主中获得AMPylation能力.
- 病毒劫持AMPylation路径可能会增强病毒感染和传播.
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