相关实验视频

Updated: Jul 13, 2025

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI

Published on: July 12, 2012

在多个发育期和青少年口语学习和记忆期间,早期接触

Alexa Friedman¹, Samantha Schildroth¹, Julia A Bauer²

¹Department of Environmental Health, Boston University School of Public Health, Boston, USA.

Neurotoxicology and teratology

|October 13, 2023

概括

早期生活中的 (Mn) 暴露时间影响青少年的认知功能. 产前的Mn与较少的记忆错误有有益的关联,而儿童时期的Mn与更好的回忆有关,特别是在男性中.

科学领域:

环境健康环境健康
神经科学是一个神经科学.
发展心理学发展心理学

背景情况:

(Mn) 是一种必需的营养素,但在高水平下是有毒的.
神经发育结果对暴露的时间敏感.
有限的前性数据存在于早期Mn暴露和青少年认知.

研究的目的:

调查早期接触和青少年认知功能之间的关联.
为了确定暴露的时间 (产前,产后,童年) 是否影响认知结果.
根据暴露水平,评估青少年的口头学习和记忆.

主要方法:

140名意大利青少年 (10-14岁) 参与了金属暴露对公共健康的影响研究.
在落叶牙中测量了含量,使用激光除质谱法来估计不同早期生命期的暴露.
青少年的口头学习和记忆被评估使用加利福尼亚儿童口头学习测试 (CVLT-C).
多变量回归模型和多个信息模型被用来分析牙 Mn 水平和认知得分之间的关联.

主要成果:

产前牙的翻倍与犯入侵错误的几率降低有关 (OR = 0.23).
儿童接触与短暂的无延迟回忆 (ß = 0.47) 有好处,男性 (ß = 0.94) 观察到更强效应.
没有发现产后暴露与认知结果的显著关联.

结论:

接触的时间是它与认知功能相关的关键因素.
产前和儿童暴露期间似乎对青少年的语言学习和记忆有不同的影响.
需要进一步的研究来阐明这些依赖时间的影响背后的机制.

关键词:

关键时期是关键时期.早期的生活早期生活是一种.记忆记忆记忆记忆记忆神经发育神经发育易感性易感性易感性

更多相关视频

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze

Published on: October 29, 2019

Use of an Eight-arm Radial Water Maze to Assess Working and Reference Memory Following Neonatal Brain Injury

Use of an Eight-arm Radial Water Maze to Assess Working and Reference Memory Following Neonatal Brain Injury

Published on: December 4, 2013

相关概念视频

Higher Mental Functions of Brain: Learning and Memory

Higher Mental Functions of Brain: Learning and Memory

Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...

Attention-Deficit/Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....