人类中的多二 (PCB) 半衰期:系统性审查
Ifeoluwa Grace Idowu1, David Megson2, Guuske Tiktak3
1Chemistry Matters Inc, Calgary, Canada.
Chemosphere
|October 13, 2023
概括
在人类中,多二 (PCB) 半衰期因特定的PCB和个体因素而异. 本综述整合了报告的半衰期,建议在未来对PCB暴露的研究中使用一致的术语.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 人类健康风险评估
背景情况:
- 多双 (PCB) 是持久性有机污染物,已有记录的人类健康影响.
- 了解PCB半衰期对于准确评估人类暴露和长期健康风险至关重要.
- 现有的文献报告了PCB半衰期数据的显著变化,需要进行全面的审查.
研究的目的:
- 从科学文献中系统地审查和整合各种PCB在人类中所报告的半衰期.
- 确定影响PCB半衰期变异性的因素.
- 在未来的研究中推标准化术语来报告PCB半衰期.
主要方法:
- 根据PRISMA指南进行了系统的文献审查.
- 包括近1000篇同行评审的出版物,重点关注26篇报告人类PCB半衰期的文章.
- 分析的数据主要来自北美对疑似暴露于PCB的个体的研究.
主要成果:
- 报告的PCB半衰期在不同PCB同源体和同一同源体内有很大差异.
- 低化PCB的半衰期通常比高化PCB的半衰期更短.
- 半衰期估计受到包括PCB体内负荷,化程度,性别,年龄,BMI和吸烟状况在内的因素的显著影响.
结论:
- PCB 半衰期不均;它们在 PCB 同源和个人之间存在显著差异.
- 与一般人群相比,职业暴露的人群可能表现出较短的PCB半衰期.
- 准确解释PCB暴露研究需要仔细考虑影响单个PCB半衰期的因素.
更多相关视频
00:05In Silico Modeling Method for Computational Aquatic Toxicology of Endocrine Disruptors: A Software-Based Approach Using QSAR Toolbox
Published on: August 28, 2019
14.0K
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
6.1K
相关概念视频
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:23Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
173
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
173