在胚胎发育期间,交感神经系统的前和后神经元中的可塑性
April Ratliff1, Dobromila Pekala1, Peter Wenner2
1Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322.
eNeuro
|October 13, 2023
概括
交感前神经元 (SPNs) 呈现出恒常性可塑性,在减少了突触输入后增加了细胞内化物水平. 后质神经元 (PGN) 没有表现出类似的恒常调整.
科学领域:
- 神经科学是一个神经科学.
- 自主神经系统生理学 自主神经系统生理学
- 细胞可塑性 细胞可塑性
背景情况:
- 交感前质神经元 (SPN) 对自主神经系统功能至关重要,集成中央输入来控制外围后质神经元 (PGN).
- 了解调节SPN和PGN兴奋度和同情语调的机制是有限的.
- SPN与体力运动神经元具有共同的发育起源,体力运动神经元表现出恒常性可塑性 (HP).
研究的目的:
- 调查SPN是否表现出与体质运动神经元相似的恒常性可塑性.
- 为了确定PGN中是否存在恒温机制,SPN的突触点.
主要方法:
- 利用一个胚胎模型,减少了SPN和PGN激发性突触输入.
- 在突触阻塞后的SPN中评估细胞内化物水平的变化.
- 在体内和体外突触输入减少后评估了PGN刺激性.
主要成果:
- 在激发性突触输入减少2天后,SPNs显示细胞内化物水平显著增加,这表明GABAergic突触缩放.
- 这种SPNs的恒常性可塑性表明在建立基线刺激性方面发挥了作用.
- 无论是体内还是体外,对PGN的突触输入减少都没有诱导它们的兴奋度的恒常性调整.
结论:
- SPN 具有恒常性可塑性机制,特别是GABAergic 突触缩放,这可能会调节发育早期的同情性音调.
- PGNs缺乏类似的恒常性调整能力,突出了中枢和外围交感神经系统组件之间的差异.
- 这些发现有助于了解同情神经系统内激发性的差异调节.
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