治疗阿司匹林加重的呼吸系统疾病:未来会怎样?
Erin K O'Brien1, Elina Jerschow2, Rohit D Divekar2
1Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN, USA.
Otolaryngologic clinics of North America
|October 13, 2023
概括
阿司匹林加重的呼吸道疾病 (AERD) 是一种严重的疾病,与鼻和喘有关. 通过病史或阿司匹林挑战进行早期查对于及时和密集治疗至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
背景情况:
- 阿司匹林加重的呼吸道疾病 (AERD) 是一个独特的临床实体.
- 它的特点是喘,慢性鼻炎与鼻 (CRSwNP),以及对阿司匹林/NSAIDs的敏感性.
- 术后的AERD往往表现为严重的症状和高的多复发率.
研究的目的:
- 突出AERD的诊断标准和临床意义.
- 强调对患有CRSwNP和喘的患者进行AERD查的重要性.
- 概述AERD目前和潜在的治疗策略.
主要方法:
- 诊断依赖于患者详细的阿司匹林或非类固醇抗炎药物 (NSAIDs) 副作用病史.
- 药物审查以确定可能掩盖阿司匹林敏感性的药物是必不可少的.
- 亚司匹林挑战测试可用于确定的诊断.
主要成果:
- 患有CRSwNP和患有AERD的喘患者在外科手术后更有可能出现鼻息肉复发.
- 这些患者往往会经历更严重的喘恶化.
- 选确定可能受益于特定AERD管理协议的个人.
结论:
- 建议在CRSwNP和喘患者中对AERD进行系统查.
- 早期识别有助于实施量身定制的,密集的治疗计划.
- 有效的管理可能涉及内镜外科手术,每日阿司匹林脱敏,白血修饰剂或生物疗法.
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