在患有消化不良症状的受试者中患有乳清性疾病的血清流行率. 一项针对墨西哥人口的研究
C Durán-Rosas1, J Lara-Carmona1, K Hernández-Flores1
1Laboratorio de Fisiología Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz, Mexico.
Revista de gastroenterologia de Mexico (English)
|October 13, 2023
概括
病 (CD) 的血清发病率在墨西哥个体与腹症状和对照人群中是相似的. 基于这些发现,不建议在患有消化不良的墨西哥患者中对CD进行查.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 病 (CD) 是一种自身免疫性肠病,通常伴有腹,但也可能出现腹性症状,如上胃疼痛.
- 以前的研究表明,在消化不良患者中,CD的患病率可能达到7%.
研究的目的:
- 为了确定墨西哥人口中患有消化不良症状的乳清性疾病 (CD) 的血清流行率.
- 为了比较患有腹不良的个体与无症状受试者的对照组之间的CD血清流行率.
主要方法:
- 一项病例控制研究涉及427名献血者,他们填写了PAGI-SYM消化不良的问卷.
- 测量IgA抗体对组织转质胺酶2 (IgA anti-tTG2) 和IgG抗体对除甲基胺 (IgG anti-DGP) 的测量,以评估CD血清学.
主要成果:
- 在427名参与者中,有87名 (20.3%) 患有消化不良症状,340名 (79.6%) 无症状.
- CD血清学在1.15%的消化不良患者和1.18%的无症状对照中呈阳性.
- 在消化不良和对照组之间没有观察到CD血清发病率的显著差异 (p=0.59).
结论:
- 患有消化不良症状的墨西哥人中乳清性疾病的血清流行率约为1%,这在统计学上与对照组没有差异.
- 根据这项研究的发现,在墨西哥患有消化不良的患者中,常规查胰腺疾病在临床上并不合理.
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