燃烧后的骨肌肉消耗是通过在早期流动阶段降低合成信号来调节的.
Dorien Dombrecht1, Ulrike Van Daele2, Birgit Van Asbroeck1
1Department of Rehabilitation Sciences & Physiotherapy, Research Group MOVANT, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
Burns : journal of the International Society for Burn Injuries
|October 13, 2023
概括
严重的烧伤会通过改变蛋白质合成和分解途径引发肌肉消耗,特别是影响Soleus (SOL) 肌肉,而不是扩展体长 (EDL). 这项研究有助于制定策略,以对抗燃烧后肌肉损失.
科学领域:
- 生物医学科学 生物医学科学
- 生理学 生理学 生理学
- 肌肉生物学 肌肉生物学
背景情况:
- 烧伤诱导了代谢性应激反应,导致骨肌肉消耗.
- 了解燃烧后肌肉消耗机制对于开发干预措施至关重要.
研究的目的:
- 为了研究严重的头皮烧伤对骨肌肉人类形态学和大鼠关键蛋白质表达的影响.
- 为了确定潜在的分子机制后燃烧肌肉消耗.
主要方法:
- 雌性大鼠经历了假冒,10%或40%的总体表面积伤灼伤.
- 肌肉重量,纤维类型组成和蛋白质表达 (eEF2,pAKT,MURF1,Atrogin-1,FOXO3A) 在受伤后10天被分析.
- 评估了线粒体功能 (COX/SDH) 和亡 (caspase-3) 的情况.
主要成果:
- 严重烧伤的老鼠在Soleus (SOL) 肌肉和Extensor Digitorum Longus (EDL) 肌肉中体重增加减少和肌肉对身体体重比较低.
- 在EDL肌肉中,总纤维较少,而在SOL肌肉中,燃烧后1型纤维增加,2型纤维减少.
- 严重的烧伤导致eEF2和pAKT的表达减少,SOL中的MURF1/Atrogin-1增加 (但EDL中的MURF1减少),并且在两个肌肉中降低了FOXO3A,而不会影响线粒体功能或亡.
结论:
- 烧伤导致肌肉人类形态和蛋白质调节发生显著变化,影响蛋白质合成和分解途径.
- 在严重的烧伤后,Soleus肌肉表现出比Extensor Digitorum Longus肌肉更明显的代谢变化.
- 这些发现提供了关于燃烧后肌肉消耗和潜在治疗点的分子基础的见解.
相关概念视频
01:24Muscle Recovery and Fatigue
2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.2K
01:26Cross-bridge Cycle
117.6K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
117.6K
01:19Regulation of Metabolism
9.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.5K
01:28Disorders of the Skeletal Muscle
973
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
973
02:36Cells Coordinate Growth and Proliferation
4.5K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.5K