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性别特异性肠道失生症在多部位损伤后仍然存在
Jennifer A Munley1, Lauren S Kelly2, Gwoncheol Park3
1Department of Surgery and Sepsis and Critical Illness Research Center, University of Florida College of Medicine, Gainesville, FL. Electronic address: https://twitter.com/jen_munley.
Surgery
|October 13, 2023
概括
严重的创伤会导致持续的肠道微生物组变化,男性和女性之间存在差异. 雌性大鼠在受伤后一周显示微生物多样性下降和独特的细菌特征,强调性别是创伤反应的关键因素.
科学领域:
- 微生物学 微生物学
- 创伤研究研究创伤研究
- 主体微生物群的相互作用
背景情况:
- 临床前研究表明,在创伤后的男性中,严重的肠道失生症,早期观察到性别特异的微生物差异.
- 宿主性别对创伤引起的肠道微生物组改变的长期影响仍然基本上是未知的.
- 这项研究调查了严重创伤损伤后七天内性特异性肠道微生物组变化的持久性.
研究的目的:
- 为了确定肠道微生物群多样性和组成的性别特异性是否在创伤损伤后7天内持续存在.
- 评估结合多创伤的慢性压力对特定性别微生物组变化的影响.
- 为了确定特征性性别特异性创伤后失生症的特定微生物种群.
主要方法:
- 雄性和雌性Sprague-Dawley大鼠经历了多创伤 (有或没有慢性克制压力) 或作为对照.
- 在受伤后的0日,3日和7日收集了便样本,用于16SrRNA测序.
- 微生物的α-多样性 (Chao1,Shannon) 和β-多样性使用微生物生态学的定量洞察 (QIIME) 生物信息学进行了分析.
主要成果:
- 多创伤和压力在第3天显著降低了两性肠道微生物的α-多样性,持续到第7天.
- 在第7天,与雄性相比,雌性大鼠的Chao1多样性明显较低 (P=.02).
- 微生物组组成在第7天有所不同,女性的Mucispirillum增加,男性的Ruminococcus和Akkermansia增加.
结论:
- 多部门创伤会导致持续的,性别特定的肠道失调.
- 女性在创伤后一周显示微生物多样性下降和独特的"病生物体"特征.
- 性是影响创伤结果的关键生物变量,需要精准医学方法.
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