在Plasmodium falciparum中,有许多途径导致了素抗性
Kushankur Pandit1, Namita Surolia2, Souvik Bhattacharjee3
1Department of Biology, Indian Institute of Science Education and Research, Pune, India.
Trends in parasitology
|October 13, 2023
概括
疟疾寄生虫的阿尔特米西宁耐药性是复杂的,涉及到已知的PfKelch13标记者之外的多个分子途径. 了解这些多样化的机制对于开发新的疟疾控制战略至关重要.
科学领域:
- 疟疾学 疟疾学
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
背景情况:
- 疟疾寄生虫中新兴的艺术素 (ART) 耐药性对全球健康构成重大挑战.
- PfKelch13中的突变是ART耐药性的关键标志物,影响寄生虫的过程,如血红蛋白吸收和细胞应激反应.
研究的目的:
- 审查与素抗性相关的分子,转录和代谢途径.
- 探索ART耐药性的复杂性,包括PfKelch13独立的机制.
主要方法:
- 关于艺术素素抗性机制研究的文献综述.
- 分析与寄生虫耐药性相关的分子,细胞和遗传数据.
主要成果:
- PfKelch13突变与降低的血红蛋白内细胞分裂,展开的蛋白质反应 (UPR),升高的PI3P和刺激的自有关.
- 存在独立于PfKelch13的耐药性途径,涉及显著的寄生虫代谢组和转录组重构.
- 抗素耐药性是多因素的,这表明没有单一的通用标识符.
结论:
- 抗素抵抗是一种复杂的现象,由多种分子和细胞适应驱动.
- 了解细胞异质性,环境压力和代谢/转录变化的相互作用对于对抗ART耐药性至关重要.
相关概念视频
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Symbiosis
28.4K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
28.4K
Diversity of Protists II
22
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
22
Development of Antibiotic Resistance
19
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
19


