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Updated: Jul 13, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

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化学因子受体CCR5和CXCR4二元化的结构基础

Daniele Di Marino1,2,3, Paolo Conflitti4, Stefano Motta5

  • 1Department of Life and Environmental Sciences - New York-Marche Structural Biology Centre (NY-MaSBiC), Polytechnic University of Marche, Via Brecce Bianche, 60131, Ancona, Italy.

Nature communications
|October 13, 2023
PubMed
概括

这项研究揭示了G蛋白结合受体 (GPCR),特别是CCR5和CXCR4如何形成二元体. 了解这些二分化机制为设计针对艾滋病毒,癌症和炎症疾病的药物提供了基础.

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