放射治疗重塑瘤的微环境,以增强免疫治疗敏感性
Senbo Liu1,2, Wenkang Wang3, Shengyun Hu1
1Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China.
Cell death & disease
|October 13, 2023
概括
癌症免疫疗法表现出有限的成功,但将其与放射治疗 (RT) 结合可能会改善结果. 通过改变瘤微环境 (TME),RT增强了抗瘤免疫力,为癌症治疗提供了一个有前途的策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 放射学 放射学是一门学科.
背景情况:
- 癌症免疫疗法,特别是免疫检查点封锁,已经彻底改变了癌症治疗,但在许多癌症中有效性有限.
- 放射治疗 (RT) 不仅消除瘤细胞,还调节瘤微环境 (TME),以促进抗瘤免疫反应.
研究的目的:
- 审查RT对TME细胞和非细胞组成部分的多方面的影响.
- 讨论RT方式对瘤免疫力的影响以及将RT与免疫治疗结合的临床影响.
主要方法:
- 关于研究放射治疗和瘤免疫之间的相互作用的综合文献综述.
- 分析RT对TME内的免疫细胞 (T细胞,髓质细胞) 和非细胞成分 (乳酸盐,细胞外囊泡) 的影响.
主要成果:
- RT显著影响T细胞受体谱,各种T细胞子集,以及TME内的代谢.
- RT影响髓状细胞,包括与瘤相关的巨细胞,树突细胞,髓状细胞衍生的抑制细胞,中性粒细胞和氨基粒细胞.
- 乳酸和细胞外囊泡等非细胞成分也受到RT的调节,影响免疫格局.
结论:
- 将RT与免疫疗法结合在一起,通过协同调节TME来增强抗瘤反应,这是一种有希望的策略.
- 了解RT对瘤免疫力的复杂影响对于优化组合疗法和改善具有挑战性的癌症的临床结果至关重要.
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