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Updated: Jul 13, 2025

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
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Published on: May 18, 2009

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对P2X4受体的全抑制的结构性见解

Cheng Shen1, Yuqing Zhang2, Wenwen Cui2

  • 1State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Bioactive Small Molecules, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Neurobiology, School of Life Sciences, Fudan University, Shanghai, 200438, China.

Nature communications
|October 13, 2023
PubMed
概括

研究人员确定了P2X4受体的冷EM结构与对抗剂BX430和BAY-1797. 这些发现揭示了全抑制剂如何与P2X4通道结合,为神经病痛药物开发提供了洞察力.

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