神经发育迟缓的儿童的体:MRI标准定性评估与自动定量分析对比
Natacha Mandine1, Elsa Tavernier2, Till Hülnhagen3,4,5
1Pediatric Radiology Department, CHRU of Tours, Clocheville Hospital, Tours, France.
European radiology experimental
|October 13, 2023
概括
在神经发育迟缓的儿童中,用于分析体 (CC) 的自动化工具的准确性比放射科医生更高. 这种定量MRI分析有助于检测微妙的CC异常.
科学领域:
- 神经成像是一种神经成像.
- 儿科神经学 儿科神经学
- 放射学 放射学是一门学科.
背景情况:
- 体 (CC) 是一个关键的大脑结构.
- 在神经发育迟缓的儿童中评估CC异常具有临床意义.
- 标准的定性放射学评估有其局限性.
研究的目的:
- 将标准定性放射学评估的诊断准确性与神经发育迟缓儿童中CC评估的自动定量工具进行比较.
- 评估自动体积和放松度核磁共振分析的实用性.
主要方法:
- 73名患有神经发育迟缓的儿童的潜在招生,接受1.5T脑磁共振扫描,使用MP2RAGE序列.
- 两个盲目放射科医生对CC的定性评估.
- 使用QuantiFIRE工具对大脑体积和T1放松度进行定量分析,与健康队列进行比较.
- 使用德隆测试对诊断准确性的统计比较.
主要成果:
- 在57.5%的病例中,CC是正常的,在27.4%的病例中是低可塑的,在15.1%的病例中是多变的.
- 在35.6%的儿童中发现T1放松度值异常.
- 自动化工具 (QuantiFIRE) 对于正常和低可塑性CC (p=0.003) 的诊断准确性比放射科医生更高.
- 观察到高的虫间协议 (科恩 κ = 0.91).
结论:
- 对CC的自动体积和放松度评估可以显著帮助评估大脑结构异常,特别是微妙的异常.
- 定量MRI分析为儿科神经发育障碍的放射科医生提供了宝贵的诊断支持工具.
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