纤维素纤维素原降解产品与比的预测价值,用于动脉瘤下关节出血患者的功能不良结果:一项回顾性病例对照研究
Weida Li1,2,3, Shuangquan Zhao3,4, Xinlong Chen1,2
1Department of Neurosurgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Neurocritical care
|October 13, 2023
概括
纤维素降解产物与的比率 (FPR) 有效地预测了动脉瘤下关节出血 (aSAH) 患者的不良结果. 较高的FPR水平表明aSAH后不良功能预后的风险更大.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 纤维素降解产物 (FDP) 和对于动脉瘤下arachnoid出血 (aSAH) 患者的预后价值仍然不清楚.
- 一种新的生物标志物,即FDP与的比率 (FPR),被提议用于预测aSAH中的功能结果.
研究的目的:
- 评估FDP与比率 (FPR) 对于被诊断为aSAH的患者功能表现不佳的预测能力.
- 确立FPR作为评估aSAH后患者预后的潜在临床工具.
主要方法:
- 对425名aSAH患者的回顾性分析.
- 不利的结果被定义为修改后的兰金尺度 (mRS) 3-6分,在3个月后.
- 采用多变量后勤回归和接收器操作特征 (ROC) 曲线分析,并根据FPR进行倾向得分匹配.
主要成果:
- FPR水平与mRS等级有显著的相关性 (斯皮尔曼的r=0.410,P<0.001).
- 不良结果的独立预测因素包括年龄,白细胞计数,,世界神经外科协会联合会等级和FPR.
- 与单个变量相比,FPR表现出优越的预测潜力,在高FPR组的后倾向性得分匹配 (39.7%对13.2%,P<0.001) 中,预后不佳的比例显著更高.
结论:
- FDP与的比率 (FPR) 是aSAH患者功能表现不佳的独立预测指标.
- 作为临床医生在评估aSAH患者的功能预后方面的一种有价值的工具,FPR显示出希望.
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