全球抗脂综合征评分 (GAPSS) 在患有系统性红斑狼的患者中
F A Cheldieva1, T M Reshetnyak2, A A Shumilova2
1Laboratory of Thromboinflammation, Nasonova Research Institute of Rheumatology, Moscow, Russia. fariza_cheldieva@mail.ru.
Doklady. Biochemistry and biophysics
|October 13, 2023
概括
全球抗脂综合征评分 (GAPSS) 有效评估俄罗斯系统性红斑狼患者的血栓形成和产科风险. 一个GAPSS得分为6或更高的识别个体有高风险的血管并发症.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 抗脂抗体 (aPL) 与临床表现的风险增加有关,包括血栓形成和产科并发症.
- 全球抗脂综合征评分 (GAPSS) 是一个有效的工具来量化这种风险,包括aPL和心血管因素.
- 在不同患者群体中验证GAPSS,例如在俄罗斯联邦患有系统性红斑狼 (SLE) 的患者群体中验证GAPSS,对于其临床效用至关重要.
研究的目的:
- 为了验证全球抗脂综合征评分 (GAPSS) 在被诊断为全身性红斑狼 (SLE) 的俄罗斯患者队列中.
- 评估GAPSS得分与SLE患者血栓形成和产科病理的发生之间的关联.
- 确定最佳的GAPSS值,用于分层的高风险的重复性血管并发症或产科问题患者.
主要方法:
- 研究了115名患有SLE的患者队列,包括患有或没有抗脂综合征 (APS) 和/或aPL的患者.
- 患者数据包括动脉,静脉或联合血栓形成史以及与怀孕相关的产科并发症.
- 计算GAPSS得分并与临床结果相关联;进行接收器操作特征 (ROC) 分析以评估诊断准确性.
主要成果:
- 患有血栓形成或产科病理的患者表现出明显更高的GAPSS分数 (7.17 ± 5.64) 与没有 (4.48 ± 4.55; p = 0.0003) 的患者相比.
- 在GAPSS水平和血栓形成之间发现了显著的关联 (p = 0.001),在动脉血栓形成与静脉血栓形成 (p = 0.01) 中的得分更高.
- 对于GAPSS,ROC分析给出了0.697的曲线下的面积 (AUC),表明了中等的歧视力.
结论:
- 全球抗脂综合征评分 (GAPSS) 是评估俄罗斯联邦SLE患者复发性血栓形成和/或产科病理的风险的一个有价值的工具.
- 建议GAPSS值≥6用于识别患有重复性血管并发症高风险的SLE患者.
- 需要进一步的前性研究来证实GAPSS在这个人群中的预测价值.
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