科里斯在ICU使用引起的毒性:一个单一中心的经验
Isa Kilic1, Yavuz Ayar2, İlkay Ceylan3
1Department of Anesthesiology and Intensive Care, Ministry of Health, Bursa City Hospital , Bursa, Turkey. kilicisaicu@gmail.com.
BMC nephrology
|October 13, 2023
概括
血管压缩剂的使用与接受胆固醇治疗的患者急性损伤 (AKI) 有关. 这一发现促进了在重症监护病房中更安全地使用胆固醇,以治疗多药耐药性感染.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- 胆固醇对于治疗多药耐药性格拉姆阴性细菌感染至关重要.
- 胆固醇诱导的急性损伤 (AKI) 是重症监护病房的一个重大问题.
- 识别胆固醇诱导的AKI的危险因素对于患者的安全至关重要.
研究的目的:
- 为了确定与胆固醇诱导的AKI相关的风险因素.
- 促进在重症监护机构中更安全地给予胆固醇.
- 引导临床实践管理由多药耐药病原体引起的感染.
主要方法:
- 成年患者接受静脉注射胆固醇至少48小时的回顾性观察研究.
- 从2020年1月到2020年12月在第三级护理医院的重症监护病房收集的数据.
- 基于病改善全球结果 (KDIGO) 标准的AKI诊断和分期.
主要成果:
- 在148名患者中,54名 (36%) 在胆固醇治疗期间发生AKI.
- 单变量分析确定了年龄,并发症指数,APACHE II评分,胆固醇持续时间,基线肌素,血管压缩剂使用和万科米辛作为显著的危险因素.
- 多变量分析显示,血管压缩剂的使用是AKI的独立预测因子 (OR:3.14,p=0.06).
结论:
- 血管压缩剂的使用在接受胆固醇治疗的危急病患者中与AKI独立相关.
- 这一发现强调了在接受胆固醇和血管压缩剂的患者中仔细监测功能的必要性.
- 结果支持开发策略,以减轻在胆固醇治疗期间的AKI风险.
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