与共变量平衡相关的倾向性得分权重在估计总体危险比率时使用分布式生存数据
Chen Huang1, Kecheng Wei1, Ce Wang1
1Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China.
BMC medical research methodology
|October 13, 2023
概括
一种用于多站点生存数据的新方法通过在不共享个人数据的情况下平衡共变量来改善危险比率估计. 这种方法在分布式研究环境中提高了准确性和效率.
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 数据科学数据科学数据科学
背景情况:
- 在多站点研究中,个人级别的数据共享具有挑战性.
- 现有的方法,如全球或本地倾向评分,可以引入偏差或降低效率,原因是未知的共同变量异质性跨站点.
研究的目的:
- 提出一种新的方法,用于估计多站点分布式生存数据中的倾向性得分.
- 为了估计整体危险比率,同时克服数据共享的限制.
主要方法:
- 开发了一种基于共变量平衡相关标准的倾向得分方法,将全球和本地倾向得分结合起来.
- 仅使用摘要级信息,应用该方法来估计分布式生存数据的整体危险比率.
- 通过模拟研究和现实数据分析验证了该方法.
主要成果:
- 与全球和本地倾向评分方法相比,拟议的方法在估计总体危险比率方面表现得更好,不论地点数量或样本大小如何.
- 在同质和异质共变量设置下观察到一致的结果.
- 该方法的结果与聚合个人级数据分析相同,并且在真实数据中发现重大影响的可能性更高.
结论:
- 与共变量平衡相关的倾向得分方法在与全球或本地方法相比,对于分布在多个地点的生存数据更优越.
- 这种方法可以在没有跨站点的个人数据传输的情况下进行分析,并获得与聚合数据分析相当的结果.
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