原产地识别复合体子单元1 (ORC1) 是癌症中潜在的生物标志物和治疗标
Linling Wu1, Hui Chen1,2, Chao Yang3,4
1Integrated Chinese & Western Medicine Oncology Research Center, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
BMC medical genomics
|October 13, 2023
概括
原始识别综合体1 (ORC1) 在大多数癌症中过度表达,可以作为诊断生物标志物. 这项研究表明ORC1抑制瘤免疫力,表明其作为治疗点的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 原产地识别综合体1 (ORC1) 是原产地识别综合体的一个关键子单位.
- 在DNA复制启动过程中,ORC1起着至关重要的作用.
研究的目的:
- 研究ORC1在各种人类癌症中的功能和临床意义.
- 探索ORC1作为潜在的诊断生物标志物和瘤学治疗点.
主要方法:
- 利用癌症基因组图集 (TCGA) 和基因表达总汇 (GEO) 数据库来分析瘤和正常组织中的ORC1表达.
- 评估了ORC1表达和免疫细胞透水平之间的相关性.
- 进行了共同表达基因分析,路径丰富分析,并构建了一个蛋白质-蛋白质相互作用 (PPI) 网络.
- 在使用免疫组织化学 (IHC) 的瘤组织中验证了ORC1表达.
主要成果:
- 发现ORC1在大多数分析的瘤中表达高.
- 提高ORC1表达与几种癌症类型 (例如ACC,LIHC,PAAD) 的晚期病理阶段和不良预后相关.
- 在不同癌症中,ORC1与免疫细胞透有差异性相关性 (例如,ACC和KICH呈阳性,THYM呈阴性).
- 同表达分析确定了与ORC1相关的CDCA3,GSG2,KIF2C,NCAPH和PLK1等基因,丰富分析指出了细胞质,ATP结合和细胞分裂中的作用.
结论:
- 在大多数瘤中,ORC1过度表达,并显示出作为新型诊断生物标记物的潜力.
- ORC1可能在抑制瘤免疫力方面发挥作用.
- ORC1代表了癌症治疗的潜在治疗标.
更多相关视频
13:19Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
16.6K
10:27Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
7.3K
相关概念视频
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K