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通过基于多的细胞同时输送二极体坎普托西因和e6,用于化学光动力学协同疗法

Zhaopei Guo¹, Ka Hong Wong¹, Enze Li¹

¹State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, SAR, China.

Chinese medicine

|October 14, 2023

概括

这项研究开发了一种新的纳米粒子系统,用于联合化学-光动力学癌症治疗. 该系统改善了药物的溶解性和输送,在临床前研究中增强了抗癌疗效.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

光动力学疗法 (PDT) 与化疗相结合,在癌症治疗方面表现有前途.
挑战包括药物和光敏剂的溶解性差和非特异性的生物分布.
克服这些局限性对于临床翻译至关重要.

研究的目的:

开发一种基于聚的纳米尺度药物输送系统,用于增强化学光动力学癌症治疗.
改善化疗剂和光敏感剂的溶解性和生物分布.
创建一个针对瘤微环境的系统.

主要方法:

通过将e6 (Ce6) 与聚L-氨酸) -b-聚烯氨酸 (PKF) 结合,制造一种基于聚类的两性聚合物.
在聚合物中封装二度坎普托丁 (DCPT) 形成纳米粒子 (PCD).
用敏感酸的聚乙烯糖醇 (PEG) 修改PCD,以获得最终的药物递送系统 (PPCD).

主要成果:

DCPT (99%) 和Ce6 (73.5%) 的高封装效率.
敏感于酸的PEG层在pH7.4时屏蔽了正电荷,并在酸性瘤微环境中被移除,增强了细胞吸收.
增加细胞内活性氧物种 (ROS) 和在细胞和动物模型中验证的增强抗癌疗效.

结论:

开发的PPCD系统有效地促进化疗剂和光敏感剂的溶解性和生物分布.
这种方法为推进化学光动力学癌症治疗提供了一个有希望的策略.
对于pH值敏感的纳米颗粒设计有助于向药物输送和改善治疗结果.

关键词:

在Camptothecin的营地里.化学光动力学疗法化学光动力学疗法结合性癌症疗法是癌症治疗的一种联合疗法.聚类是一种多类.

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