骨髓移植后的肝胆道疾病:377名患者的横截面研究
Maria Gabriela Fernandes Dezan1,2,3, Lourianne Nascimento Cavalcante1,2,3, Hugo Rodrigues Carvalho Silva4
1Instituto D'Or de Pesquisa e Ensino (IDOR) and Hospital São Rafael-Gastro-Hepatology Service, Hospital São Rafael, Salvador, Bahia, Brazil.
Alimentary pharmacology & therapeutics
|October 14, 2023
概括
骨髓移植 (BMT) 后肝胆道并发症很常见,影响超过一半的患者,增加死亡风险. 女性性别,先前存在的肝脏问题,以及单一的移植都会增加这种风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
- 血液学 血液学 血液学
背景情况:
- 骨髓移植 (BMT) 是血液学疾病的关键治疗方法.
- 在BMT后的肝胆道并发症显著影响患者的发病率和死亡率.
- 不同的诊断包括DILI,SALI,SOS,GVHD,病毒性肝炎,缺血性肝炎和 fulminant 肝炎.
研究的目的:
- 确定BMT后肝胆道并发症的发病率和临床特征.
- 确定与这些并发症相关的风险因素.
- 评估BMT患者肝胆病变的结果,包括死亡率.
主要方法:
- 一项横截面研究分析了2017年1月至2022年6月BMT患者的医疗记录.
- 肝胆道并发症的诊断使用了既定的标准.
- 统计分析包括几率比率来评估风险因素和结果.
主要成果:
- 在377名BMT患者中,超过一半 (55.7%) 患有肝胆道并发症.
- 增加的风险与女性性别 (OR 1.8) 相关,前BMT肝脏变化 (OR 1.72) 和均异性异基移植 (OR 3.25) 相关.
- 患有并发症的患者住院时间较长 (27.7 vs 19.3 天),死亡风险更高 (OR 4.98).
结论:
- 肝胆道并发症是BMT后常见的,并且与增加住院和死亡率有关.
- 风险因素包括女性性别,BMT前的肝脏状况和单一的移植.
- 早期识别和管理这些并发症对于改善 BMT 结果至关重要.
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