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系统性红斑狼中的细胞因子-专注于TNF-α和IL-17
Patricia Richter1, Luana Andreea Macovei1, Ioana Ruxandra Mihai1
1Department of Rheumatology and Rehabilitation, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
International journal of molecular sciences
|October 14, 2023
概括
瘤坏死因子-α (TNF-α) 和介素-17 (IL-17) 是系统性红斑狼 (SLE) 发病过程中的关键细胞因子. 虽然在狼患者中升高,但它们的治疗抑制显示出希望,但面临着像抗TNF诱导狼这样的挑战.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 自免疫性疾病 自免疫性疾病
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病.
- 细胞因子在SLE病变和进展中发挥着关键作用.
- 瘤坏死因子-α (TNF-α) 和中白素-17 (IL-17) 是对SLE具有显著兴趣的细胞因子.
研究的目的:
- 探索TNF-α和IL-17在SLE中的作用.
- 评估它们作为疾病活动生物标志物的潜力.
- 讨论它们的调制对SLE治疗的影响.
主要方法:
- 对SLE中TNF-α和IL-17的现有文献的审查.
- 对与疾病活性评分 (例如,SLEDAI) 相关联的细胞因子水平研究的分析.
- 讨论涉及细胞因子抑制的治疗策略.
主要成果:
- 在SLE中,TNF-α具有双重作用 (免疫抑制和促炎作用).
- 常常与IL-23相关的IL-17有助于SLE病变和组织损伤.
- 在SLE患者中观察到TNF-α和IL-17水平升高,尽管与疾病活动的关联是有争议的.
- 与一般人群相比,这些细胞因子的度增加.
结论:
- TNF-α和IL-17与SLE病变发生有关,并且在患者中升高.
- 针对这些细胞因子提供了潜在的治疗途径.
- 抗TNF-α治疗带有抗TNF诱导狼 (ATIL) 的风险.
- 抗IL-17疗法是一种有希望的,但尚未批准的SLE治疗选择.
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