结合绝育因素对骨植入物的结构和功能特征的影响
Nadezhda Nikolaeva1, Vladimir Rozanov1,2,3, Alexander Chernyaev1,2
1Radiation Technologies Laboratory, Institute of Physics and Technology, M.K. Ammosov North-Eastern Federal University, 677000 Yakutsk, Russia.
International journal of molecular sciences
|October 14, 2023
概括
骨植入物的联合臭氧和辐射灭菌没有显示任何负面的结构或功能变化. 这项研究优化了绝育方法,确保在重建性手术中安全使用骨移植.
科学领域:
- 生物材料科学 生物材料科学
- 消毒技术 消毒技术 消毒技术
- 组织工程是组织工程.
背景情况:
- 绝育对于重建性手术中的骨植入物安全性至关重要.
- 优化绝育方法将骨组织的结构和功能变化降到最低.
研究的目的:
- 为了评估臭氧和辐射结合灭菌后骨组织的结构和功能变化.
- 调查两阶段绝育方法 (臭氧-氧气接着辐射) 的有效性.
主要方法:
- 红外 (IR) 光谱法 红外 (IR) 光谱法 红外 (IR) 光谱法
- 扫描电子显微镜 (SEM) 具有元素分析.
- 原子力显微镜 (AFM) 的使用
- 机械分析 (维克斯微硬度)
主要成果:
- 联合臭氧和辐射灭菌并没有导致骨植入物质的负面变化.
- 作为消毒的初步步骤,暴露于臭氧对骨组织是安全的.
结论:
- 这项研究为优化骨植入物联合灭菌技术提供了基础.
- 这些发现支持在重建手术中安全使用骨植入物,以最小的组织变化.
- 这项研究有助于为生物医学应用开发有效的健康保护技术.
相关概念视频
Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
The Bone Matrix
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Bone Formation by Intramembranous Ossification
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...


