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Updated: Jul 13, 2025

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在自身免疫性疾病中表皮-半机关转换 (EMT) 的参与
Julie Sarrand1, Muhammad S Soyfoo1
1Department of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
International journal of molecular sciences
|October 14, 2023
概括
表皮-介质细胞过渡 (EMT) 在风湿性疾病中驱动纤维化. 本综述详细介绍了EMT如何在系统性硬化和类风湿性关节炎等疾病中促进病理性纤维化状态.
科学领域:
- 细胞生物学 细胞生物学
- 病理学 病理学 病理学
- 类风湿病学 类风湿病学
背景情况:
- 表皮-介质细胞过渡 (EMT) 是一种生物过程,涉及表皮细胞的丧失和介质细胞特征的增加.
- EMT与癌症的发展,转移和器官纤维化有关.
- 纤维化,以过度的细胞外基质沉积为特征,损害器官功能,并可能导致衰竭.
研究的目的:
- 审查目前对EMT在类风湿性疾病病理生理学中的作用的理解.
- 探索自身免疫疾病中的慢性炎症与EMT诱导的纤维化之间的联系.
主要方法:
- 关于EMT和风湿性疾病中的纤维化现有研究的文献综述.
- 综合证据,将慢性炎症状态与EMT激活联系起来.
- 分析EMT衍生的肌纤维细胞对纤维瘤病理学的贡献.
主要成果:
- 纤维化中关键的肌纤维细胞的很大一部分来自经过EMT的上皮细胞.
- 系统性硬化症,类风湿性关节炎,SLE,Sjögren综合征和IBD等自身免疫性疾病的慢性炎症可以触发EMT.
- 在这些类风湿性疾病中,EMT激活有助于病理性纤维化状态的发展.
结论:
- 在各种类风湿性疾病中,EMT是纤维化背后的关键机制.
- 了解EMT的作用为我们提供了关于自身免疫性疾病中纤维化并发症的发病过程的见解.
- 对EMT调制的进一步研究可能会揭示对类风湿性纤维性疾病的治疗策略.
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