狼性炎风险因素和生物标志物:一个更新
Yves Renaudineau1, Wesley Brooks2, Julie Belliere3
1Department of Immunology, Referral Medical Biology Laboratory, University Hospital of Toulouse, Institut National de la Santé Et de la Recherche Médicale (INSERM) U1291, Centre National de la Recherche Scientifique (CNRS) U5051, 31400 Toulouse, France.
International journal of molecular sciences
|October 14, 2023
概括
狼性炎 (LN),一种严重的全身性红斑狼 (SLE) 并发症,需要更好的生物标志物用于早期诊断,监测和治疗. 目前的策略进展缓慢,突出了需要个性化,生物标志物引导的护理,以改善患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 狼性炎 (LN) 是系统性红斑狼 (SLE) 最严重的表现,显著影响患者的发病率和死亡率.
- 尽管在过去十年中进行了广泛的研究以表征疾病阶段和开发生物标志物,但改善结果的临床进展仍然有限.
- 早期死亡通常与活跃的SLE或感染有关,而晚期死亡率与慢性疾病和有毒治疗有关.
研究的目的:
- 审查对狼性炎 (LN) 描述和开发各种疾病阶段生物标志物的努力.
- 突出对准确,个性化的生物标志物的未满足需求,以指导治疗策略.
- 强调治疗到目标方法在管理LN中的重要性.
主要方法:
- 审查了解LN病原和生物标志物发展的最新进展.
- 对LN目前的诊断和监测策略的分析.
- 对SLE和LN的治疗指南和新型治疗方法的评估.
主要成果:
- 为了确定SLE前阶段,早期诊断,疾病监测,爆发预防和功能管理的生物标志物,已经做出了重大努力.
- 尽管有这些努力,但患者生存率的改善和长期并发症的减少仍不够理想.
- 现有的疗法和指导方针还没有足够缓解与LN相关的早期或晚期死亡率.
结论:
- 个性化治疗到目标的策略对于管理狼性炎 (LN) 是必不可少的.
- 对于一套全面的准确生物标志物,有着至关重要的未满足的需求,以作为护理标准.
- 生物标志物必须针对每个疾病阶段进行定制,以有效指导治疗并改善患者的治疗结果.
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