了解非酒精性脂肪肝疾病和甲状腺疾病之间的关系
Paulina Vidal-Cevallos1, Sofía Murúa-Beltrán Gall1, Misael Uribe1
1Obesity and Digestive Disease Unit, Medica Sur Clinic and Foundation, Av. Puente de Piedra 150, Toriello Guerra, Tlalpan, Mexico City 14050, Mexico.
International journal of molecular sciences
|October 14, 2023
概括
低甲状腺症在非酒精性脂肪性肝病 (NAFLD) 中很常见. 甲状腺激素受体βagonists通过改善肝脏脂肪和炎症来治疗NAFLD有希望.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 影响着相当一部分人口.
- 甲状腺激素 (THs) 在肝脏脂质和碳水化合物代谢中起着至关重要的作用.
- 在NAFLD患者中观察到甲状腺功能低下的高患病率 (22.4%),这表明存在联系.
研究的目的:
- 审查病理生理学和流行病学证据,将甲状腺功能障碍与NAFLD联系起来.
- 探索THs和选择性肝脏甲状腺激素受体-β (THR-β) 激动剂对肝脏脂质代谢的影响.
- 突出THR-β激动剂在NAFLD管理中的治疗潜力.
主要方法:
- 审查关于甲状腺功能障碍,NAFLD病原和治疗干预措施的现有文献.
- 分析甲状腺刺激激素 (TSH),TH水平和慢性炎症在NAFLD中的作用.
- 检查选择性肝脏THR-β激动剂的作用机制,如Resmetirom.
主要成果:
- 甲状腺功能障碍,特别是甲状腺功能低下,与NAFLD的发展和进展密切相关.
- 在甲状腺功能低下症引起的NAFLD中,THR-β活性至关重要.
- 选择性肝脏THR-β激动剂Resmetirom在减少肝脏脂肪和改善非酒精性脂肪肝炎 (NASH) 中表现出有效性.
结论:
- 用激动剂向THR-β是NAFLD的一个有前途的治疗策略.
- 对THR-β激动剂的进一步研究和开发对于NAFLD治疗是有必要的.
- 了解甲状腺激素和肝脏代谢之间的相互作用是有效管理NAFLD的关键.
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