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Updated: Jul 13, 2025

A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue
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低水平的粉样蛋白前体蛋白 (APP) 促进神经发生和减少人类神经干细胞中的质发生.

Raquel Coronel1,2, Victoria López-Alonso3, Marta I Gallego4

  • 1Unidad de Regeneración Neural, Unidad Funcional de Investigación de Enfermedades Crónicas, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.

International journal of molecular sciences
|October 14, 2023
PubMed
概括

人类神经干细胞 (hNSCs) 中降低调节的粉样蛋白前体蛋白 (APP) 促进细胞增殖和神经发生. 这一发现与APP过度表达效应形成鲜明对比,为APP提供了新的洞察力.

关键词:
粉样蛋白前体蛋白质的前体蛋白质是什么细胞命运规范 细胞命运规范质体的产生是质体的产生.人类神经干细胞的神经干细胞神经发生神经发生.它们的扩散和扩散.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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