身体炼作为对抗阿尔茨海默病的疾病修改替代方案:肠-肌肉-大脑合作伙伴关系
Debora Cutuli1,2, Davide Decandia1,2, Giacomo Giacovazzo2,3
1Department of Psychology, University of Rome La Sapienza, 00185 Rome, Italy.
International journal of molecular sciences
|October 14, 2023
概括
身体炼对肠道微生物群和肌肉健康产生积极影响,影响肠-大脑轴,可能预防认知能力下降和阿尔茨海默病. 这种相互作用支持大脑健康和长寿.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 阿尔茨海默病 (AD) 是痴呆的主要原因,涉及神经退行和认知障碍.
- 身体炼 (PE) 被认为可以减少炎症并预防认知能力下降.
- 肠-大脑轴涉及免疫系统,肠道微生物群 (GM) 和神经炎症,对大脑健康至关重要.
研究的目的:
- 探索体育炼对肠-大脑轴的影响,重点关注其在阿尔茨海默病中的作用.
- 研究肠道微生物群和肌肉之间的双向通信及其对认知的影响.
- 突出运动诱导因素的潜力,如虹素在缓解AD病理生理学的潜力.
主要方法:
- 审查现有的关于体育炼,肠道微生物群和神经炎症的文献.
- 对肠-肌肉-大脑轴相互作用的分析.
- 对分子机制的检查,包括SCFA生产和像虹膜素这样的肌.
主要成果:
- 身体炼有利于调节肠道微生物群的组成和多样性.
- 运动会影响肠道肌肉轴,影响肌肉代谢和SCFA的产生.
- 运动诱导的肌动素 (例如,虹膜素) 和BDNF促进神经可塑性和认知功能.
结论:
- 通过体育炼调节的肠-肌肉-大脑轴,为阿尔茨海默病提供了一个有前途的治疗点.
- 了解这些相互联系可以导致提高大脑健康,打击认知衰退和促进寿命的策略.
- 身体活动对肠道微生物群和肌肉健康的影响是其神经保护性益处的关键.
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