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Updated: Jul 13, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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作为多目标化合物的新胺:关于合成,ACHE和BACE1抑制活性和分子对接的研究

Danuta Drozdowska1, Dawid Maliszewski1, Agnieszka Wróbel1

  • 1Department of Organic Chemistry, Medical University of Białystok, Mickiewicza Street 2A, 15-222 Białystok, Poland.

International journal of molecular sciences
|October 14, 2023
PubMed
概括

研究人员合成了新型本扎米德作为乙胆酶 (AChE) 和β-分泌酶 (BACE1) 的潜在抑制剂. 一种化合物对两种酶都表现出显著的活性,这表明一种有希望的机制涉及增加酶度.

关键词:
这种抑制剂是ACHE抑制剂.阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.这是一种BACE1抑制剂.班扎米德是一种本扎米德.双重抑制剂的双重抑制剂

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