肝部特异性FGF21淘汰赛通过逆转皮质子的产生来消除卵巢切除诱导的肥胖症
Jiayu Xu1, Xinyu Shao1, Haozhe Zeng1
1College of Life Science, Sichuan Agricultural University, Ya'an 625014, China.
International journal of molecular sciences
|October 14, 2023
概括
雌激素枯竭通过提高葡萄皮质醇 (GCs) 来增加中心肥胖症. 肝脏FGF21驱动了这种GC增加,但其缺乏会加剧代谢问题,显示在肥胖和代谢健康方面具有双重作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢综合征是代谢综合征的一种.
- 肥胖问题研究研究
背景情况:
- 雌激素枯竭与中心肥胖有关,其中葡萄糖皮质醇 (GCs) 的升高是关键因素.
- 在雌激素贫乏状态下,GC产量增加的确切原因尚不清楚.
- 纤维细胞生长因子21 (FGF21) 和GC表现出一个前调节循环.
研究的目的:
- 调查一种假设,即肝脏FGF21分泌量升高会增加雌激素贫乏女性的GC产量.
- 在更年期的小鼠模型中阐明肝脏FGF21在中介中心肥胖症和相关代谢变化的作用.
主要方法:
- 利用卵巢切除 (OVX) 的小鼠作为绝经后妇女的模型.
- 产生了肝脏特异性FGF21淘汰赛 (FGF21 LKO) 的小鼠.
- 评估循环激素水平 (皮质,胰岛素),基因表达 (Hsd11b1),身体组成和代谢参数 (耐葡萄糖,胰岛素抵抗).
主要成果:
- OVX增加了循环皮质和内脏脂肪Hsd11b1的表达,导致内脏肥胖.
- 肝脏特异性FGF21淘汰赛 (FGF21 LKO) 取消了OVX诱导的GC和内脏肥胖的增加.
- 通过降低胰岛素水平,FGF21 LKO未能改善OVX诱导的脂质不良症,肝肥胖症和胰岛素耐药性,并加剧了葡萄糖代谢功能障碍.
结论:
- 肝脏FGF21通过增强的GC生产在调解雌激素枯竭引起的中央肥胖症方面发挥着关键作用.
- 在减少肥胖的同时,缺少肝脏的FGF21信号会对胰岛素产生产生不利影响,恶化整体代谢功能障碍.
- 肝脏FGF21具有双重作用:促进中心肥胖,但可能在雌激素贫乏状态下防止严重的代谢异常.
关键词:
FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21FGF21中央肥胖中心 肥胖中心皮质类皮质类固醇.在这种情况下,胰岛素胰岛素.代谢综合征 代谢综合征这是一次过度切除术.更多相关视频
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