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佩里拉在口腔状细胞癌的治疗效果

Chia-Huei Lee¹, Yu-Hsin Tsao^1,2, Yui-Ping Weng³

¹National Institute of Cancer Research, National Health Research Institutes, Miaoli 35053, Taiwan.

International journal of molecular sciences

|October 14, 2023

概括

梨花叶的,咖啡酸 (CA) 和迷酸 (RA) 抑制了口腔癌细胞的生长. 这些化合物增强化学疗法和EGFR向治疗在口腔状细胞癌 (OSCC) 治疗中的疗效.

科学领域:

药理学药理学是一个学科.
在瘤学瘤学.
自然产品化学化学

背景情况:

佩里拉叶提取物 (PLE) 具有与癌症治疗相关的药理特性.
口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
确定OSCC的新型治疗剂至关重要.

研究的目的:

调查叶提取物 (PLE) 和其主要化合物咖啡酸 (CA) 和酸 (RA) 对口腔状细胞癌 (OSCC) 的抗癌作用.
探索CA和RA作为辅助疗法的潜力,与现有的癌症治疗相结合.

主要方法:

高性能液体染色学 (HPLC) 用于识别和量化PLE中的化合物.
进行了体外测试,以评估PLE,CA和RA对OSCC细胞活力,互白素-1β分泌和殖民地形成的影响.
评估了CA和RA对EGFR激活和对gefitinib敏感性的影响.
与低剂量西斯普拉丁治疗进行了比较.

主要成果:

PLE,CA和RA以剂量依赖的方式显著抑制OSCC细胞活力.
在OSCC细胞中,CA和RA抑制了互白素-1β的分泌.
使用CA和CA/RA混合物的长期治疗诱导了EGFR激活,增加了对gefitinib的敏感性.
CA,RA,和它们的组合显示出比低剂量西斯普拉丁对殖民地形成的更强大的抑制作用,可能是通过诱导亡.

结论:

叶的,特别是CA和RA,对OSCC细胞表现出显著的抗癌活性.
可以将CA和RA用作辅助疗法,以提高OSCC的化疗和EGFR向治疗的疗效.
这些发现支持开发来自perilla的化合物,以改善OSCC管理.

关键词:

咖啡酸是一种咖啡酸.西斯普拉丁 (cisplatin) 是一种制剂.皮肤上生长因子受体 (EGFR)盖菲提尼布 (gefitinib) 是一种药物.介质蛋白 (IL) - 1ββ 是一种蛋白质.口腔状细胞癌 (OSCC) 是一种佩里拉 (Perilla) 是一种危险的东西.罗斯马林酸是一种酸.

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