扰乱平衡的后果 平衡的后果
Jacek Baj1, Wojciech Flieger1, Aleksandra Barbachowska2
1Chair and Department of Anatomy, Medical University of Lublin, 20-090 Lublin, Poland.
International journal of molecular sciences
|October 14, 2023
概括
(Mn) 是重要的,但有毒的,特别是对大脑. 这篇评论探讨了Mn暴露,大脑积累以及与神经退行性和代谢性疾病的联系.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- (Mn) 是一种重要的微量元素,对许多身体功能至关重要,包括能量代谢和抗氧化剂防御.
- 然而,过度接触可以导致神经毒性,特别是影响中枢神经系统 (CNS),并可能导致神经退行性疾病.
- 广泛暴露是通过吸入,摄入和皮肤接触发生的,某些人群由于遗传因素,脏疾病,缺铁或饮食习惯而面临更高风险.
研究的目的:
- 审查有关暴露源和大脑积累的当前知识.
- 讨论生物标志物参考值和金属相互作用中的争议.
- 检查平衡受损与神经退行性,生育性,传染性和代谢性疾病之间的联系.
主要方法:
- 关于暴露及其生物效应的现有数据的综合文献综述.
- 对支持大脑中积累的实验证据的分析.
- 讨论和其他重要和有毒金属之间的竞争相互作用.
- 综合证据,将平衡中断与各种疾病状态联系起来.
主要成果:
- 大脑中的积累得到实验数据的支持,与帕金森病和阿尔茨海默病等神经退行性疾病有显著的关联.
- 关于不同生物矩阵中生物标记物的参考值存在争议.
- 在吸收和运输方面与其他金属 (如铁,,) 竞争,影响其恒温.
- 的恒常性受损与神经退行性疾病,生育能力受损,传染病和代谢疾病 (如2型糖尿病和肥胖) 的易感性增加有关.
结论:
- 作为必需营养素和神经毒素的双重作用需要仔细管理暴露水平.
- 需要进一步的研究来澄清在神经退行和代谢疾病中的确切作用,并建立可靠的生物标志物.
- 了解金属相互作用对于评估毒性和开发有效干预措施至关重要.
更多相关视频
08:36Functional Neuroimaging Using Ultrasonic Blood-brain Barrier Disruption and Manganese-enhanced MRI
Published on: July 12, 2012
15.1K
08:29Measuring Liver Mitochondrial Oxygen Consumption and Proton Leak Kinetics to Estimate Mitochondrial Respiration in Holstein Dairy Cattle
Published on: November 30, 2018
11.4K
相关概念视频
01:27The Periodic Table and Organismal Elements
17.1K
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
17.1K
01:26Toxic Reactions: Overview
992
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
992
01:31Essential Minerals for Bone Health
4.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.0K
01:30Vitamins
746
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
746
01:26Minerals
331
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
Major...
Major...
331
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K