基于充满抗菌和细胞静止药物的可吸收多基酸的微粒的特征
Anastasiya V Murueva1,2, Anna M Shershneva2, Ekaterina I Shishatskaya1,2,3
1Institute of Biophysics SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS" (IBP SB RAS), 50/50 Akademgorodok, 660036 Krasnoyarsk, Russia.
International journal of molecular sciences
|October 14, 2023
概括
可生物降解的多基酸盐 (PHAs) 用于制造用于药物输送的微粒. 这些PHA显示出开发具有抗菌和抗瘤功能的有效,现代药物输送系统的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 控制的药物输送系统在药理学中至关重要.
- 微粒设计取决于制造方法和载体材料的特性.
- 聚酸酸 (PHAs) 是可生物降解的聚合物,有可能用于药物输送应用.
研究的目的:
- 使用各种可降解的PHAs获得和描述微粒.
- 评估制备方法,聚合物组成和药物负载对微粒物特性的影响.
- 评估药物加载,封装效率和PHA微粒中的药物的体外释放.
主要方法:
- 使用了四种不同化学成分和性能的可降解PHA.
- 制造了微粒,并描述了它们的尺寸 (0.865.0μm) 和泽塔电位 (-18到-50mV).
- 纳入药物 (ceftriaxone,5-fluorouracil) 在含添加剂的基于PHA的复合微粒中.
主要成果:
- 成功生产了具有控制大小和令人满意的泽塔潜力的优质微粒.
- 描述了药物载荷含量,封装效率和体外药物释放概况.
- 复合微粒对大肠杆菌和HeLa培养物的抗菌和抗瘤作用已被证明.
结论:
- PHAs非常适合创建先进和高效的药物输送系统.
- 开发的微粒显示出有前途的治疗效果,表明它们在制药应用中的潜力.
- 基于PHA的微粒提供了一个多功能平台,用于控制各种治疗剂的释放.
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